Methotrexate is a high-risk drug, i.e. serious patient harm can occur as a result of errors involving incorrect frequency (daily rather once weekly), incorrect strength tablets, incorrect strength tablets, or from an adverse drug reaction. Care must be taken with methotrexate use at all stages of medication use, including at transitions of care. Click here to view IMSN’s Safety Alert on the Use of Once Weekly Oral Methotrexate
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